CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus-Reference-Cited by-同舟云学术

CpG pretreatment enhances antiviral T-cell immunity against cytomegalovirus

Published:2013-07-04 Issue:1 Volume:122 Page:55-60
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Ong Monique L.¹²,Wikstrom Matthew E.¹²,Fleming Peter¹²,Estcourt Marie J.¹²,Hertzog Paul J.³,Hill Geoffrey R.⁴,Andoniou Christopher E.¹²,Degli-Esposti Mariapia A.¹²

Affiliation:

1. Immunology and Virology Program, Centre for Ophthalmology and Visual Science, University of Western Australia, Crawley, WA, Australia;

2. Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA, Australia;

3. Centre for Innate Immunity and Infectious Diseases, Monash Institute of Medical Research, Clayton, VIC, Australia; and

4. Bone Marrow Transplantation Laboratory, Queensland Institute of Medical Research, Brisbane, QLD, Australia

Abstract

Key Points Fully functional CD8 T-cell responses, control of infection, and protection from organ pathology are attained without cross-presentation. Direct presentation generates responses that limit disease and ensure host survival despite the presence of immunomodulatory viral proteins.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/1/55/1369081/55.pdf

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4. Viral interference with antigen presentation.;Yewdell;Nat Immunol,2002

5. Viral interference with antigen presentation does not alter acute or chronic CD8 T cell immunodominance in murine cytomegalovirus infection.;Munks;J Immunol,2007

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