C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes-Reference-Cited by-同舟云学术

C1galt1-deficient mice exhibit thrombocytopenia due to abnormal terminal differentiation of megakaryocytes

Published:2013-08-29 Issue:9 Volume:122 Page:1649-1657
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kudo Takashi¹,Sato Takashi²,Hagiwara Kozue¹²,Kozuma Yukinori³,Yamaguchi Takashi²,Ikehara Yuzuru²,Hamada Michito¹,Matsumoto Ken¹,Ema Masatsugu¹,Murata Soichiro⁴,Ohkohchi Nobuhiro⁴,Narimatsu Hisashi²,Takahashi Satoru¹

Affiliation:

1. Department of Anatomy and Embryology, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan;

2. Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology, Open Space Laboratory, Tsukuba, Ibaraki, Japan; and

3. School of Medical Sciences, and

4. Department of Surgery, Faculty of Medicine, University of Tsukuba, Tennodai, Tsukuba, Ibaraki, Japan

Abstract

Key Points Mucin-type O-glycans are required for terminal differentiation of megakaryocytes and platelet production. The expression of GPIbα protein is strongly reduced in O-glycans–defective megakaryocytes and platelets.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/122/9/1649/1372979/1649.pdf

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