Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome-Reference-Cited by-同舟云学术

Clonal selection in xenografted TAM recapitulates the evolutionary process of myeloid leukemia in Down syndrome

Published:2013-05-23 Issue:21 Volume:121 Page:4377-4387
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Saida Satoshi¹,Watanabe Ken-ichiro¹,Sato-Otsubo Aiko²,Terui Kiminori³,Yoshida Kenichi²,Okuno Yusuke²,Toki Tsutomu³,Wang RuNan³,Shiraishi Yuichi⁴,Miyano Satoru⁴,Kato Itaru¹,Morishima Tatsuya¹,Fujino Hisanori¹,Umeda Katsutsugu¹,Hiramatsu Hidefumi¹,Adachi Souichi⁵,Ito Etsuro³,Ogawa Seishi²,Ito Mamoru⁶,Nakahata Tatsutoshi⁷,Heike Toshio¹

Affiliation:

1. Department of Pediatrics, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

2. Cancer Genomics Project, Graduate School of Medicine, University of Tokyo, Tokyo, Japan;

3. Department of Pediatrics, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan;

4. Laboratory of DNA Information Analysis, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan;

5. Department of Human Health Sciences, Graduate School of Medicine, Kyoto University, Kyoto, Japan;

6. Laboratory Animal Research Department, Central Institute for Experimental Animals, Kawasaki, Japan; and

7. Department of Clinical Application, Center for iPS Cell Research and Application, Kyoto University, Kyoto, Japan

Abstract

Key Points Genetically heterogeneous subclones with varying leukemia-initiating potential exist in neonatal transient abnormal myelopoiesis. This novel xenograft model of transient abnormal myelopoiesis may provide unique insight into the evolutionary process of leukemia.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/21/4377/1366178/4377.pdf

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