Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy-Reference-Cited by-同舟云学术

Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy

Published:2013-06-13 Issue:24 Volume:121 Page:4821-4831
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Boyerinas Benjamin¹,Zafrir Maya¹,Yesilkanal Ali E.¹,Price Trevor T.¹,Hyjek Elizabeth M.²,Sipkins Dorothy A.¹

Affiliation:

1. Department of Medicine, Section of Hematology/Oncology, University of Chicago, Chicago, IL; and

2. Department of Pathology, University of Chicago, Chicago, IL

Abstract

Key Points Stromal OPN anchors leukemia cells in prodormancy BM niches. Inhibiting this interaction leads dormant cells to proliferate, sensitizing them to chemotherapy.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/24/4821/1366375/4821.pdf

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