Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL-Reference-Cited by-同舟云学术

Immunogenetics shows that not all MBL are equal: the larger the clone, the more similar to CLL

Published:2013-05-30 Issue:22 Volume:121 Page:4521-4528
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Vardi Anna¹,Dagklis Antonis²,Scarfò Lydia²,Jelinek Diane³,Newton Darren⁴,Bennett Fiona⁴,Almeida Julia⁵,Rodriguez-Caballero Arancha⁵,Allgood Sallie⁶,Lanasa Mark⁶,Cortelezzi Agostino⁷⁸,Orlandi Ester⁸⁹,Veronese Silvio¹⁰,Montillo Marco⁸¹⁰,Rawstron Andy⁴,Shanafelt Tait³,Orfao Alberto⁵,Stamatopoulos Kostas¹¹¹,Ghia Paolo²⁸

Affiliation:

1. Hematology Department and Hematopoietic Cell Transplantation Unit, G. Papanicolaou Hospital, Thessaloniki, Greece;

2. Division of Molecular Oncology and Department of Onco-Hematology, Universita Vita-Salute San Raffaele and Istituto Scientifico San Raffaele, Milan, Italy;

3. Department of Immunology, Mayo Clinic, Rochester, MN;

4. Haematological Malignancy Diagnostic Service, St. James’s Institute of Oncology, Leeds Teaching Hospitals, Leeds, United Kingdom;

5. Centro de Investigación del Cáncer and Department of Medicine, University of Salamanca, Salamanca, Spain;

6. Department of Medicine, Duke University Medical Center, Durham, NC;

7. Department of Medical Sciences, Hematology 1 Centro Trapianti di Midollo Osseo University of Milan, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;

8. Rete Ematologica Lombarda, Milan, Italy;

9. Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo and University of Pavia, Pavia, Italy;

10. Niguarda Ca’ Granda Hospital, Milan, Italy; and

11. Institute of Applied Biosciences, Center for Research and Technology Hellas, Thessaloniki, Greece

Abstract

Key Points Low-count and high-count monoclonal B-cell lymphocytosis (MBL) have distinct immunogenetic signatures, with only the latter resembling CLL. Rather than a true premalignant condition, low-count MBL may merely reflect immune senescence or result from persistent antigen stimulation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/121/22/4521/1366704/4521.pdf

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