An evolutionarily conserved program of B-cell development and activation in zebrafish

Author:

Page Dawne M.1,Wittamer Valerie23,Bertrand Julien Y.24,Lewis Kanako L.2,Pratt David N.1,Delgado Noemi1,Schale Sarah E.1,McGue Caitlyn1,Jacobsen Bradley H.1,Doty Alyssa1,Pao Yvonne5,Yang Hongbo6,Chi Neil C.6,Magor Brad G.7,Traver David25

Affiliation:

1. Department of Biology, Point Loma Nazarene University, San Diego, CA;

2. Division of Biological Sciences, University of California, San Diego, La Jolla, CA;

3. Interdisciplinary Research Institute, Université Libre de Bruxelles, Brussels, Belgium;

4. Department of Pathology and Immunology, University of Geneva, Geneva, Switzerland;

5. Department of Cellular and Molecular Medicine, and

6. Department of Medicine, Division of Cardiology, University of California, San Diego, La Jolla, CA; and

7. Department of Biological Sciences, University of Alberta, Edmonton, AB, Canada

Abstract

Key Points B cells appear in zebrafish by 3 weeks of development, supporting previous data that this is the transition point to adult hematopoiesis. Shifting sites of B-cell development likely occur in all jawed vertebrates.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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