Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis-Reference-Cited by-同舟云学术

Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis

Published:2017-04-13 Issue:15 Volume:129 Page:2161-2171
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Sun Junjiang¹,Hua Baolai²,Livingston Eric W.³,Taves Sarah³⁴^ORCID,Johansen Peter B.⁴,Hoffman Maureane⁵,Ezban Mirella⁴,Monroe Dougald M.⁶,Bateman Ted A.³⁷,Monahan Paul E.¹⁸⁹^ORCID

Affiliation:

1. Gene Therapy Center, University of North Carolina, Chapel Hill, NC;

2. Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China;

3. Department of Biomedical Engineering, University of North Carolina, Chapel Hill, NC;

4. Global Research, Novo Nordisk A/S, Maløv, Denmark;

5. Department of Pathology, Duke University and Durham Veterans Affairs Medical Centers, Durham, NC;

6. Division of Hematology/Oncology, Department of Medicine,

7. Department of Radiation Oncology, and

8. Harold R. Roberts Comprehensive Hemophilia Diagnosis and Treatment Center, University of North Carolina, Chapel Hill, NC; and

9. Shire Plc, Cambridge, MA

Abstract

Key Points Joint and bone healing abnormalities are demonstrated in hemophilic mice that are not solely because of the amount of blood in their joints. Following initial hemostasis, extended FIX activity is needed in the week after hemarthrosis to normalize osteochondral healing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/15/2161/1399899/blood734053.pdf

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3. Repeated autologous intraarticular blood injections as an animal model for joint pain in haemophilic arthropathy;Boettger;Arthritis Res Ther,2013

4. Blood-induced joint damage: longterm effects in vitro and in vivo;Hooiveld;J Rheumatol,2003

5. Wound healing in hemophilia B mice and low tissue factor mice;Monroe;Thromb Res,2010

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