IL-4/CXCL12 loop is a key regulator of lymphoid stroma function in follicular lymphoma

Author:

Pandey Shubham1,Mourcin Frédéric1ORCID,Marchand Tony12ORCID,Nayar Saba3,Guirriec Marion1,Pangault Céline14ORCID,Monvoisin Céline1,Amé-Thomas Patricia14ORCID,Guilloton Fabien1,Dulong Joelle14,Coles Mark5,Fest Thierry14,Mottok Anja67,Barone Francesca3,Tarte Karin14ORCID

Affiliation:

1. UMR U1236, INSERM, Université Rennes 1, Etablissement Français du Sang Bretagne, Equipe Labellisée Ligue Contre le Cancer, Rennes, France;

2. Centre Hospitalier Universitaire (CHU) de Rennes, Service d’Hématologie Clinique, Rennes, France;

3. Centre for Translational Inflammation Research, Institute of Inflammation and Ageing, College of Medical and Dental Sciences, University of Birmingham Research Laboratories, Queen Elizabeth Hospital, Birmingham, United Kingdom;

4. CHU de Rennes, Pôle de Biologie, Rennes, France;

5. Centre for Immunology and Infection, Department of Biology, Hull York Medical School, University of York, York, United Kingdom;

6. Centre for Lymphoid Cancer, British Columbia Cancer Agency, Vancouver, BC, Canada; and

7. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada

Abstract

Key Points FL-infiltrating stromal cells overexpress CXCL12, which triggers FL B-cell migration, adhesion, and activation. Polarization into CXCL12hi stroma involves IL-4+ TFH cells, unlike malignant B cells, revealing an indirect protumoral activity of FL-TFH cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference61 articles.

1. Hallmarks of cancer: the next generation;Hanahan;Cell,2011

2. Fibroblast heterogeneity in the cancer wound;Öhlund;J Exp Med,2014

3. Cancer associated fibroblasts: the dark side of the coin;Cirri;Am J Cancer Res,2011

4. Origins of the tumor microenvironment: quantitative assessment of adipose-derived and bone marrow-derived stroma;Kidd;PLoS One,2012

5. Immunological hallmarks of stromal cells in the tumour microenvironment;Turley;Nat Rev Immunol,2015

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