Slowed decay of mRNAs enhances platelet specific translation-Reference-Cited by-同舟云学术

Slowed decay of mRNAs enhances platelet specific translation

Published:2017-04-27 Issue:17 Volume:129 Page:e38-e48
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mills Eric W.¹²,Green Rachel¹^ORCID,Ingolia Nicholas T.²³^ORCID

Affiliation:

1. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, MD;

2. Department of Embryology, Carnegie Institution of Washington, Baltimore, MD; and

3. Department of Molecular Cell Biology, Center for RNA Systems Biology, Glenn Center for Aging Research, University of California Berkeley, Berkeley, CA

Abstract

Key Points Ribosome profiling of primary human platelets defines the platelet translatome, derived from a biased subset of MK mRNAs. Restoration of the ribosome rescue/mRNA surveillance factor Pelota, which is normally absent in wild-type platelets, promotes RNA decay.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/17/e38/1400076/blood736108.pdf

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