The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity-Reference-Cited by-同舟云学术

The amyloidogenic light chain is a stressor that sensitizes plasma cells to proteasome inhibitor toxicity

Published:2017-04-13 Issue:15 Volume:129 Page:2132-2142
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Oliva Laura¹,Orfanelli Ugo¹,Resnati Massimo¹,Raimondi Andrea²,Orsi Andrea³,Milan Enrico¹,Palladini Giovanni⁴⁵,Milani Paolo⁴⁵,Cerruti Fulvia⁶,Cascio Paolo⁶,Casarini Simona⁴⁵,Rognoni Paola⁴⁵,Touvier Thierry⁷,Marcatti Magda⁸,Ciceri Fabio⁸⁹,Mangiacavalli Silvia¹⁰,Corso Alessandro¹⁰,Merlini Giampaolo⁴⁵,Cenci Simone¹⁹^ORCID

Affiliation:

1. Unit of Age Related Diseases, Division of Genetics and Cell Biology,

2. Imaging Research Center, and

3. Unit of Protein Transport and Secretion, Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milan, Italy;

4. Amyloidosis Research and Treatment Center, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Policlinico San Matteo, Pavia, Italy;

5. Department of Molecular Medicine, University of Pavia, Pavia, Italy;

6. Department of Veterinary Sciences, University of Turin, Turin, Italy;

7. Unit of Biology of Myelin, Division of Genetics and Cell Biology, and

8. Hematology and Bone Marrow Transplantation Unit, Department of Oncohematology, San Raffaele Scientific Institute, Milan, Italy;

9. Università Vita-Salute San Raffaele, Milan, Italy; and

10. Division of Hematology, Fondazione IRCCS Policlinico San Matteo, Pavia, Italy

Abstract

Key PointsAmyloidogenic PCs show unique PI susceptibility and altered organelle homeostasis, consistent with defective autophagy. Amyloidogenic LC production is an intrinsic cellular stressor that sensitizes to PI toxicity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/15/2132/1399837/blood730978.pdf

Reference57 articles.

1. Dangerous small B-cell clones;Merlini;Blood,2006

2. Predictors of survival in patients with systemic light-chain amyloidosis and cardiac involvement initially ineligible for stem cell transplantation and treated with oral melphalan and dexamethasone;Lebovic;Br J Haematol,2008

3. Treatment with intravenous melphalan and dexamethasone is not able to overcome the poor prognosis of patients with newly diagnosed systemic light chain amyloidosis and severe cardiac involvement;Dietrich;Blood,2010

4. Treating advanced cardiac damage in light chain amyloidosis: still an unmet need;Merlini;Haematologica,2014

5. Amyloidosis: pathogenesis and new therapeutic options;Merlini;J Clin Oncol,2011

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