Normal hematologic parameters and fetal hemoglobin silencing with heterozygous IKZF1 mutations

Author:

Abdulhay Nour123,Fiorini Claudia123,Kumánovics Attila45,Sun Ashleigh A.6,Hansen-Rejali Jeannette457,Voelkerding Karl V.45,Rosenzweig Sergio D.5,Hill Harry R.457,Sankaran Vijay G.123

Affiliation:

1. Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA;

2. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA;

3. Broad Institute of Massachusetts Institute of Technology and Harvard, Cambridge, MA;

4. ARUP Institute for Clinical and Experimental Pathology, ARUP Laboratories, Salt Lake City, UT;

5. Department of Pathology, University of Utah, Salt Lake City, UT;

6. Immunology Service, Department of Laboratory Medicine, Clinical Center, and Primary Immune Deficiency Clinic, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD; and

7. Departments of Pediatrics and Medicine, University of Utah, Salt Lake City, UT

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference25 articles.

1. Awakening lineage potential by Ikaros-mediated transcriptional priming.;Yoshida;Curr Opin Immunol,2010

2. Multiple hematopoietic defects and delayed globin switching in Ikaros null mice.;Lopez;Proc Natl Acad Sci USA,2002

3. A mechanism for Ikaros regulation of human globin gene switching.;Keys;Br J Haematol,2008

4. The role of Ikaros in human erythroid differentiation.;Dijon;Blood,2008

5. The switch from fetal to adult hemoglobin.;Sankaran;Cold Spring Harb Perspect Med,2013

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