GVHD prevents NK-cell–dependent leukemia and virus-specific innate immunity

Author:

Bunting Mark D.1,Varelias Antiopi12,Souza-Fonseca-Guimaraes Fernando3456,Schuster Iona S.78,Lineburg Katie E.9,Kuns Rachel D.1,Fleming Peter78,Locke Kelly R.1,Huntington Nicholas D.45,Blazar Bruce R.1011,Lane Steven W.21213,Tey Siok-Keen1213,MacDonald Kelli P. A.9,Smyth Mark J.23,Degli-Esposti Mariapia A.78,Hill Geoffrey R.1213

Affiliation:

1. Bone Marrow Transplantation Laboratory, Immunology Department, Queensland Institute of Medical Research (QIMR) Berghofer Medical Research Institute, Brisbane, QLD, Australia;

2. School of Medicine, University of Queensland, Brisbane, QLD, Australia;

3. Immunology in Cancer and Infection Laboratory, Immunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia;

4. Molecular Immunology Division, Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia;

5. Department of Medical Biology and

6. Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Melbourne, VIC, Australia;

7. Immunology and Virology Program, Centre for Ophthalmology and Visual Science, The University of Western Australia, Crawley, WA, Australia;

8. Centre for Experimental Immunology, Lions Eye Institute, Nedlands, WA, Australia;

9. Antigen Presentation and Immunoregulation Laboratory, Immunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia;

10. Masonic Cancer Center and

11. Division of Blood and Marrow Transplantation, Department of Pediatrics, University of Minnesota, Minneapolis, MN;

12. Gordon and Jessie Gilmour Leukemia Research Laboratory, Immunology Department, QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia; and

13. The Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia

Abstract

Key Points Donor T cells compete for IL-15 with NK cells during GVHD, resulting in profound defects in NK-cell reconstitution. GVHD impairs NK-cell–dependent leukemia and pathogen-specific immunity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3