Lymphangiogenesis is a feature of acute GVHD, and VEGFR-3 inhibition protects against experimental GVHD-Reference-Cited by-同舟云学术

Lymphangiogenesis is a feature of acute GVHD, and VEGFR-3 inhibition protects against experimental GVHD

Published:2017-03-30 Issue:13 Volume:129 Page:1865-1875
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Mertlitz Sarah¹,Shi Yu¹,Kalupa Martina¹,Grötzinger Carsten²,Mengwasser Jörg¹,Riesner Katarina¹,Cordes Steffen¹,Elezkurtaj Sefer³,Penack Olaf¹

Affiliation:

1. Department of Hematology, Oncology, and Tumor Immunology, and

2. Department of Hepatology and Gastroenterology and Molecular Cancer Research Center, Tumor Targeting Laboratory, Charité University Medicine, Campus Virchow Clinic, Berlin, Germany; and

3. Institute for Pathology, Charité University Medicine, Campus Mitte, Berlin, Germany

Abstract

Key Points aGVHD after hematopoietic stem cell transplantation is associated with lymphangiogenesis in the intestinal tract and lymph nodes. Inhibition of lymphangiogenesis by antibodies against VEGFR-3 ameliorated aGVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/13/1865/1399352/blood734210.pdf

Reference44 articles.

1. Interaction of tumor cells and lymphatic vessels in cancer progression;Alitalo;Oncogene,2012

2. Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts;Hautz;Transpl Int,2014

3. Lymphatic endothelial progenitor cells contribute to de novo lymphangiogenesis in human renal transplants;Kerjaschki;Nat Med,2006

4. Lymph angiogenesis after lung transplantation and relation to acute organ rejection in humans;Dashkevich;Ann Thorac Surg,2010

5. Critical role of VEGF-C/VEGFR-3 signaling in innate and adaptive immune responses in experimental obliterative bronchiolitis;Krebs;Am J Pathol,2012

Cited by 14 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Lymphangiogenesis in the liver of biliary atresia;BMC Gastroenterology;2024-08-15

2. Lymphangiogenesis in the Liver of Biliary Atresia;2024-04-22

3. Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targets;Signal Transduction and Targeted Therapy;2024-01-03

4. The novel role of lymphatic vessels in the pathogenesis of ocular diseases;Progress in Retinal and Eye Research;2023-09

5. Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis;International Journal of Molecular Sciences;2021-06-08