TPL2 kinase regulates the inflammatory milieu of the myeloma niche-Reference-Cited by-同舟云学术

TPL2 kinase regulates the inflammatory milieu of the myeloma niche

Published:2014-05-22 Issue:21 Volume:123 Page:3305-3315
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Hope Chelsea¹²,Ollar Samuel J.¹²,Heninger Erika²,Hebron Ellen¹²,Jensen Jeffrey L.¹²,Kim Jaehyup¹²,Maroulakou Ioanna³,Miyamoto Shigeki²⁴,Leith Catherine⁵,Yang David T.⁵,Callander Natalie¹²,Hematti Peiman¹²,Chesi Marta⁶,Bergsagel P. Leif⁶,Asimakopoulos Fotis¹²

Affiliation:

1. Department of Medicine, Division of Hematology/Oncology, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI;

2. University of Wisconsin Carbone Cancer Center, Madison, WI;

3. Department of Molecular Biology and Genetics, Democritus University of Thrace, Alexandroupolis, Greece;

4. Department of Oncology, University of Wisconsin-Madison, Madison, WI;

5. Department of Pathology and Laboratory Medicine, University of Wisconsin-Madison School of Medicine and Public Health, Madison, WI; and

6. Mayo Clinic-Scottsdale, Scottsdale, AZ

Abstract

Key Points We describe a novel, druggable pathway that controls myeloma growth through macrophages in the myeloma microenvironment. Macrophages are dominant orchestrators of the inflammatory milieu of the myeloma niche.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/21/3305/1377202/3305.pdf

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