Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis-Reference-Cited by-同舟云学术

Cdk4 and Cdk6 cooperate in counteracting the INK4 family of inhibitors during murine leukemogenesis

Published:2014-10-09 Issue:15 Volume:124 Page:2380-2390
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rodríguez-Díez Esther¹,Quereda Victor¹,Bellutti Florian²,Prchal-Murphy Michaela²,Partida David¹,Eguren Manuel¹,Kollmann Karoline²,Gómez de Cedrón Marta¹,Dubus Pierre³,Cañamero Marta⁴,Martínez Dolores⁵,Sexl Veronika²,Malumbres Marcos¹

Affiliation:

1. Cell Division and Cancer Group, Spanish National Cancer Research Centre (CNIO), Madrid, Spain;

2. Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Vienna, Austria;

3. EA2406 University of Bordeaux, Bordeaux, France; and

4. Histopathology Unit, and

5. Flow Cytometry Unit, CNIO, Madrid, Spain

Abstract

Key Points A Cdk6 R31C knock-in mutation resistant to INK4 inhibitors cooperates with Cdk4 hyperactivity in the development of hematopoietic tumors. In Cdk6 R31C cells, p16INK4a increasingly binds and inhibits Cdk4, suggesting that both kinases cooperate in sequestering INK4 proteins in cancer.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/15/2380/1381511/2380.pdf

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