A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop)-Reference-Cited by-同舟云学术

A hereditary bleeding disorder resulting from a premature stop codon in thrombomodulin (p.Cys537Stop)

Published:2014-09-18 Issue:12 Volume:124 Page:1951-1956
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Langdown Jonathan¹,Luddington Roger J.¹,Huntington James A.²,Baglin Trevor P.¹^ORCID

Affiliation:

1. Cambridge Haemophilia and Thrombophilia Centre, Addenbrooke’s Hospital, Cambridge University Hospitals National Health Service Foundation Trust, Cambridge, United Kingdom; and

2. University of Cambridge, Department of Haematology, Cambridge Institute for Medical Research, Cambridge, United Kingdom

Abstract

Key Points A novel TM mutation results in shedding of active TM into the blood. Subsequent activation of the protein C anticoagulant system causes bleeding.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/12/1951/1379536/1951.pdf

Reference24 articles.

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4. The central role of thrombin in hemostasis.;Crawley;J Thromb Haemost,2007

5. Thrombin-cofactor interactions: structural insights into regulatory mechanisms.;Adams;Arterioscler Thromb Vasc Biol,2006

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