Translocation t(2;11) in CLL cells results in CXCR4/MAML2 fusion oncogene

Author:

Acunzo Mario1,Romano Giulia1,Wernicke Dorothee1,Balatti Veronica1,Rassenti Laura Z.2,dell’Aquila Marie3,Kipps Thomas J.2,Pekarsky Yuri1,Croce Carlo M.1

Affiliation:

1. Departments of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center and Medicine, The Ohio State University, Columbus, OH; and

2. Department of Medicine and

3. Cytogenetic Laboratory, School of Medicine, University of California at San Diego, La Jolla, CA

Abstract

Key Points A new translocation t(2;11)(q22.1;q21) that involves CXCR4 and MAML2 has been described and characterized in CLL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference15 articles.

1. Molecular basis of CLL.;Pekarsky;Semin Cancer Biol,2010

2. Characterization of the 13q14 tumor suppressor locus in CLL: identification of ALT1, an alternative splice variant of the LEU2 gene.;Bullrich;Cancer Res,2001

3. Oncogenes and cancer.;Croce;N Engl J Med,2008

4. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome.;Druker;N Engl J Med,2001

5. Glivec (STI571, imatinib), a rationally developed, targeted anticancer drug.;Capdeville;Nat Rev Drug Discov,2002

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