The bleeding score predicts clinical outcomes and replacement therapy in adults with von Willebrand disease

Author:

Federici Augusto B.12,Bucciarelli Paolo1,Castaman Giancarlo3,Mazzucconi Maria G.4,Morfini Massimo5,Rocino Angiola6,Schiavoni Mario7,Peyvandi Flora1,Rodeghiero Francesco3,Mannucci Pier Mannuccio8

Affiliation:

1. Angelo Bianchi Bonomi Hemophilia Thrombosis Center, Istituto Ricerca e Cura di Carattere Scientifico (IRCCS) Ca’ Granda, Foundation Maggiore Policlinico Hospital, Milan, Italy;

2. Hematology and Transfusion Medicine, L. Sacco University Hospital and Department of Clinical Sciences & Community Health, University of Milan, Milan, Italy;

3. Division of Hematology, San Bortolo Hospital, Vicenza, Italy;

4. Hemophilia Center, Department of Hematology, University of Rome, Rome, Italy;

5. Hemophilia Center, Careggi Hospital, Florence, Italy;

6. Hemophilia Center, Pellegrini Hospital, Naples, Italy;

7. Hemophilia Thrombosis Center, Ospedale Policlinico, Bari, Italy; and

8. Scientific Direction, IRCCS Cà Granda Foundation Maggiore Policlinico Hospital, Milan, Italy

Abstract

Key Points The bleeding score helps to predict clinical outcomes in adult patients with von Willebrand disease. High bleeding scores correlate with intensive on-demand therapy and may identify cases requiring regular prophylaxis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference42 articles.

1. Von Willebrand’s disease in the year 2003: towards the complete identification of gene defects for correct diagnosis and treatment.;Castaman;Haematologica,2003

2. Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor.;Sadler;J Thromb Haemost,2006

3. Principles of care for the diagnosis and treatment of von Willebrand disease.;Castaman;Haematologica,2013

4. Epidemiological investigation of the prevalence of von Willebrand’s disease.;Rodeghiero;Blood,1987

5. Prevalence of von Willebrand disease in children: a multiethnic study.;Werner;J Pediatr,1993

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