Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma-Reference-Cited by-同舟云学术

Next-generation sequencing of peripheral B-lineage cells pinpoints the circulating clonotypic cell pool in multiple myeloma

Published:2014-06-05 Issue:23 Volume:123 Page:3618-3621
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Thiele Benjamin¹,Kloster Marie¹,Alawi Malik²,Indenbirken Daniela³,Trepel Martin¹,Grundhoff Adam³,Binder Mascha¹

Affiliation:

1. University Medical Center Hamburg-Eppendorf, Hubertus Wald Tumorzentrum, University Cancer Center Hamburg, Department of Oncology, Hematology, Bone Marrow Transplantation with Section Pneumology, Hamburg, Germany;

2. University Medical Center Hamburg-Eppendorf, Bioinformatics Service Facility, Hamburg, Germany; and

3. Heinrich-Pette-Institute, Leibniz-Institute for Experimental Virology, Hamburg, Germany

Abstract

Key Points Clonotypic B cells, long suspected to represent circulating stem-like cells, are consistently absent in the blood of myeloma patients. Malignant plasma cells frequently circulate in the peripheral blood, show evidence for clonal evolution, and may spread the disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/23/3618/1378398/3618.pdf

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5. Intraclonal homogeneity of clonotypic immunoglobulin M and diversity of nonclinical post-switch isotypes in multiple myeloma: insights into the evolution of the myeloma clone.;Taylor;Clin Cancer Res,2002

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