Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias-Reference-Cited by-同舟云学术

Dual mechanisms by which miR-125b represses IRF4 to induce myeloid and B-cell leukemias

Published:2014-08-28 Issue:9 Volume:124 Page:1502-1512
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

So Alex Yick-Lun¹,Sookram Reeshelle¹,Chaudhuri Aadel A.¹²,Minisandram Aarathi¹,Cheng David¹,Xie Catherine¹,Lim Ee Lyn¹,Flores Yvette Garcia¹,Jiang Shuai¹,Kim Jocelyn Tammy¹,Keown Christopher³,Ramakrishnan Parameswaran⁴,Baltimore David¹

Affiliation:

1. Department of Biology, California Institute of Technology, Pasadena, CA;

2. Department of Radiation Oncology, Stanford University School of Medicine, Stanford, CA;

3. Department of Cognitive Science, University of California San Diego, La Jolla, CA; and

4. Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH

Abstract

Key Points MiR-125b induces tumorigenesis in myeloid cells by repressing the expression of IRF4 at the mRNA and protein level. MiR-125b promotes oncogenesis in B cells that involves selection of cells that acquire genetic deletion of the gene encoding IRF4.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/9/1502/1383367/1502.pdf

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