Treatment of chronic graft-versus-host disease with bortezomib

Author:

Pai Chien-Chun Steven1,Chen Mingyi2,Mirsoian Annie1,Grossenbacher Steven K.1,Tellez Joseph1,Ames Erik1,Sun Kai3,Jagdeo Jared1,Blazar Bruce R.4,Murphy William J.15,Abedi Mehrdad5

Affiliation:

1. Department of Dermatology and

2. Department of Pathology, School of Medicine, University of California, Davis, Sacramento, CA;

3. Institute of Hematology, Zhengzhou University People's Hospital, Zhengzhou, China;

4. Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN; and

5. Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA

Abstract

Key Points Bortezomib ameliorates sclerodermatous cGVHD responses by inhibiting germinal center B cells while maintaining GVT effects in murine models. Bortezomib provides therapeutic benefits for patients with active steroid-refractory cGVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference33 articles.

1. Advances in graft-versus-host disease biology and therapy.;Blazar;Nat Rev Immunol,2012

2. 2010 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders.;Pasquini;Clin Transpl,2010

3. Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host Disease.;Wolff;Biol Blood Marrow Transplant,2011

4. Chronic graft-versus-host disease.;Horwitz;Blood Rev,2006

5. B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways.;Allen;Blood,2012

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