Treatment of chronic graft-versus-host disease with bortezomib-Reference-Cited by-同舟云学术

Treatment of chronic graft-versus-host disease with bortezomib

Published:2014-09-04 Issue:10 Volume:124 Page:1677-1688
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Pai Chien-Chun Steven¹,Chen Mingyi²,Mirsoian Annie¹,Grossenbacher Steven K.¹,Tellez Joseph¹,Ames Erik¹,Sun Kai³,Jagdeo Jared¹,Blazar Bruce R.⁴,Murphy William J.¹⁵,Abedi Mehrdad⁵

Affiliation:

1. Department of Dermatology and

2. Department of Pathology, School of Medicine, University of California, Davis, Sacramento, CA;

3. Institute of Hematology, Zhengzhou University People's Hospital, Zhengzhou, China;

4. Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN; and

5. Department of Internal Medicine, School of Medicine, University of California, Davis, Sacramento, CA

Abstract

Key Points Bortezomib ameliorates sclerodermatous cGVHD responses by inhibiting germinal center B cells while maintaining GVT effects in murine models. Bortezomib provides therapeutic benefits for patients with active steroid-refractory cGVHD.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/10/1677/1380081/1677.pdf

Reference33 articles.

1. Advances in graft-versus-host disease biology and therapy.;Blazar;Nat Rev Immunol,2012

2. 2010 report from the Center for International Blood and Marrow Transplant Research (CIBMTR): current uses and outcomes of hematopoietic cell transplants for blood and bone marrow disorders.;Pasquini;Clin Transpl,2010

3. Consensus Conference on Clinical Practice in Chronic GVHD: Second-Line Treatment of Chronic Graft-versus-Host Disease.;Wolff;Biol Blood Marrow Transplant,2011

4. Chronic graft-versus-host disease.;Horwitz;Blood Rev,2006

5. B cells from patients with chronic GVHD are activated and primed for survival via BAFF-mediated pathways.;Allen;Blood,2012

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