A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor-Reference-Cited by-同舟云学术

A hyperactive Mpl-based cell growth switch drives macrophage-associated erythropoiesis through an erythroid-megakaryocytic precursor

Published:2015-02-05 Issue:6 Volume:125 Page:1025-1033
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Belay Eyayu¹²³,Miller Chris P.²⁴,Kortum Amanda N.²⁴,Torok-Storb Beverly³,Blau C. Anthony²⁴,Emery David W.¹²

Affiliation:

1. Department of Medicine, Division of Medical Genetics and

2. Institute for Stem Cell and Regenerative Medicine, University of Washington, Seattle, WA;

3. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; and

4. Department of Medicine, Division of Hematology, University of Washington, Seattle, WA

Abstract

Key PointsIncreasing receptor stability of an Mpl-based cell growth switch improves ex vivo expansion from cord blood CD34+ cells. Expansion includes Epo-independent, macrophage-associated erythropoiesis from a novel erythroid-megakaryocytic precursor population.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/6/1025/1386958/1025.pdf

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