Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15-Reference-Cited by-同舟云学术

Autonomous growth and increased cytotoxicity of natural killer cells expressing membrane-bound interleukin-15

Published:2014-08-14 Issue:7 Volume:124 Page:1081-1088
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Imamura Masaru¹,Shook David²,Kamiya Takahiro¹,Shimasaki Noriko¹,Chai Sally M. H.¹,Coustan-Smith Elaine¹,Imai Chihaya³,Campana Dario¹

Affiliation:

1. Department of Pediatrics, National University of Singapore, Singapore;

2. Department of Bone Marrow Transplantation and Cellular Therapy, St. Jude Children’s Research Hospital, Memphis, TN; and

3. Department of Pediatrics, Niigata University, Niigata, Japan

Abstract

Key PointsExpression of IL-15 in a membrane-bound form sustains NK cell survival and expansion in vitro and in vivo without exogenous cytokines. These NK cells have superior cytotoxicity against leukemia, lymphoma, and solid tumor cells, supporting their clinical testing.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/7/1081/1383898/1081.pdf

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