Murine coagulation factor VIII is synthesized in endothelial cells-Reference-Cited by-同舟云学术

Murine coagulation factor VIII is synthesized in endothelial cells

Published:2014-06-12 Issue:24 Volume:123 Page:3697-3705
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Everett Lesley A.¹,Cleuren Audrey C. A.²³,Khoriaty Rami N.⁴,Ginsburg David³⁵

Affiliation:

1. Department of Human Genetics, University of Michigan Medical School, Ann Arbor, MI;

2. Life Sciences Institute, University of Michigan, Ann Arbor, MI;

3. Howard Hughes Medical Institute, Chevy Chase, MD; and

4. Division of Hematology and Oncology and

5. Departments of Internal Medicine, Human Genetics, and Pediatrics, University of Michigan, Ann Arbor, MI

Abstract

Key Points Lman1 tissue-specific knockout mice reveal that endothelial cells, not hepatocytes, are the primary source of FVIII biosynthesis. F8 gene expression is heterogeneous among endothelial cell populations in different tissues.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/123/24/3697/1377051/3697.pdf

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4. Expression of factor VIII by murine liver sinusoidal endothelial cells.;Do;J Biol Chem,1999

5. Liver transplantation in hemophilia A.;Bontempo;Blood,1987

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