In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice-Reference-Cited by-同舟云学术

In utero depletion of fetal hematopoietic stem cells improves engraftment after neonatal transplantation in mice

Published:2014-08-07 Issue:6 Volume:124 Page:973-980
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Derderian S. Christopher¹²,Togarrati P. Priya¹²,King Charmin¹²,Moradi Patriss W.¹²,Reynaud Damien¹,Czechowicz Agnieszka³,Weissman Irving L.⁴,MacKenzie Tippi C.¹²

Affiliation:

1. Eli and Edythe Broad Center of Regeneration Medicine and

2. The Department of Surgery, University of California, San Francisco, San Francisco, CA;

3. The Department of Pediatrics, Boston Children's Hospital, Harvard Medical School, Boston, MA; and

4. The Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA

Abstract

Key Points In utero injection of an antibody against the c-Kit receptor can effectively deplete host HSCs in mice. In utero depletion of host HSCs leads to significantly increased engraftment after neonatal congenic hematopoietic cell transplantation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/124/6/973/1382560/973.pdf

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4. Long-term results of related myeloablative stem-cell transplantation to cure sickle cell disease.;Bernaudin;Blood,2007

5. In utero hematopoietic cell transplantation for the treatment of congenital anomalies.;Nijagal;Clin Perinatol,2012

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