Development of a comprehensive prognostic index for patients with chronic lymphocytic leukemia

Author:

Pflug Natali1,Bahlo Jasmin1,Shanafelt Tait D.2,Eichhorst Barbara F.1,Bergmann Manuela A.3,Elter Thomas1,Bauer Kathrin4,Malchau Gebhart5,Rabe Kari G.6,Stilgenbauer Stephan7,Döhner Hartmut7,Jäger Ulrich8,Eckart Michael J.9,Hopfinger Georg10,Busch Raymonde11,Fink Anna-Maria1,Wendtner Clemens-Martin3,Fischer Kirsten1,Kay Neil E.2,Hallek Michael1

Affiliation:

1. Department I of Internal Medicine and Center of Integrated Oncology Cologne Bonn, University of Cologne, Cologne, Germany;

2. Department of Internal Medicine, Division of Hematology, Mayo Clinic, Rochester, MN;

3. Department I of Internal Medicine, Hospital München-Schwabing, Munich, Germany;

4. Cochrane Hematological Malignancies Group, University of Cologne, Cologne, Germany;

5. Institute of Clinical Chemistry, University Hospital of Cologne, Cologne, Germany;

6. Department of Health Sciences Research, Mayo Clinic, Rochester, MN;

7. Department of Internal Medicine III, Ulm University, Ulm, Germany;

8. Department of Internal Medicine I, Division of Hematology and Haemostaseology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria;

9. Hämatologische und Onkologische Schwerpunktpraxis, Erlangen, Germany;

10. Department III of Internal Medicine, University Hospital of Salzburg, Salzburg, Austria; and

11. Institute for Medical Statistics and Epidemiology, Technical University Munich, Munich, Germany

Abstract

Key Points Prognostic tool for CLL patients with high discriminatory power compared with conventional clinical staging systems. Prognostication on the individual patient level independent of clinical stage.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference52 articles.

1. Chronic Lymphocytic Leukemia/small lymphocytic leukemia.;Müller-Hermelink,2008

2. Chronic lymphocytic leukaemia.;Dighiero;Lancet,2008

3. Prognostic factors in chronic lymphocytic leukemia-what do we need to know?;Cramer;Nat Rev Clin Oncol,2011

4. A new prognostic classification of chronic lymphocytic leukemia derived from a multivariate survival analysis.;Binet;Cancer,1981

5. Clinical staging of chronic lymphocytic leukemia.;Rai;Blood,1975

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