A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria-Reference-Cited by-同舟云学术

A novel role for von Willebrand factor in the pathogenesis of experimental cerebral malaria

Published:2016-03-03 Issue:9 Volume:127 Page:1192-1201
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

O’Regan Niamh¹,Gegenbauer Kristina¹,O’Sullivan Jamie M.¹,Maleki Sanaz²,Brophy Teresa M.¹,Dalton Niall¹,Chion Alain¹,Fallon Padraic G.³,Grau Georges E.²,Budde Ulrich⁴,Smith Owen P.⁵⁶,Craig Alister G.⁷,Preston Roger J. S.⁵⁸,O’Donnell James S.¹⁹

Affiliation:

1. Haemostasis Research Group, Institute of Molecular Medicine, Trinity Centre for Health Sciences, St James’s Hospital, Trinity College, Dublin, Ireland;

2. Vascular Immunology Unit, Discipline of Pathology, Sydney Medical School, University of Sydney, New South Wales, Australia;

3. Inflammation and Immunity Research Group, Institute of Molecular Medicine, St James’s Hospital, Trinity College, Dublin, Ireland;

4. MEDILYS Laborgesellschaft mbH, Asklepios Klinik Altona, Zentrales Labor, Hamburg, Germany;

5. National Children’s Research Centre, and

6. Haematology Department, Our Lady's Children's Hospital, Crumlin, Dublin, Ireland;

7. Department of Parasitology, Liverpool School of Tropical Medicine, Liverpool, United Kingdom;

8. Department of Clinical Medicine, School of Medicine, Trinity College, Dublin, Ireland; and

9. National Centre for Hereditary Coagulation Disorders, St James’s Hospital, Dublin, Ireland

Abstract

Key Points ECM is associated with an early marked increase in plasma VWF levels and accumulation of UL-VWF multimers. Following P berghei infection, VWF−/− mice survive significantly longer compared with WT controls.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/9/1192/1395879/1192.pdf

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