Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia-Reference-Cited by-同舟云学术

Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia

Published:2016-04-28 Issue:17 Volume:127 Page:2122-2130
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Nadeu Ferran¹^ORCID,Delgado Julio¹²,Royo Cristina¹,Baumann Tycho²,Stankovic Tatjana³,Pinyol Magda⁴,Jares Pedro¹²,Navarro Alba¹,Martín-García David¹,Beà Sílvia¹,Salaverria Itziar¹,Oldreive Ceri³,Aymerich Marta¹²,Suárez-Cisneros Helena⁴,Rozman Maria¹²,Villamor Neus¹²,Colomer Dolors¹²,López-Guillermo Armando¹²,González Marcos⁵,Alcoceba Miguel⁵,Terol Maria José⁶,Colado Enrique⁷,Puente Xose S.⁸,López-Otín Carlos⁸,Enjuanes Anna⁴,Campo Elías¹²⁹^ORCID

Affiliation:

1. Lymphoid Neoplasm Program, Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain;

2. Hematology Department, Hospital Clínic, Barcelona, Spain;

3. School of Cancer Sciences, University of Birmingham, Birmingham, United Kingdom;

4. Unitat de Genòmica, IDIBAPS, Barcelona, Spain;

5. Biología Molecular e Histocompatibilidad, Hospital Universitario, Salamanca, Spain;

6. Unidad de Hematología, Hospital Clínico Universitario, Valencia, Spain;

7. Servicio de Hematología y Hemoterapia, Hospital Universitario Central de Asturias, Oviedo, Spain;

8. Departamento de Bioquímica y Biología Molecular, Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain; and

9. Departament d'Anatomia Patològica, Universitat de Barcelona, Barcelona, Spain

Abstract

Key Points Clonal and subclonal mutations of NOTCH1 and TP53, clonal mutations of SF3B1, and ATM mutations in CLL have an impact on clinical outcome. Clonal evolution in longitudinal samples occurs before and after treatment and may have an unfavorable impact on overall survival.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/17/2122/1393231/2122.pdf

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