UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma-Reference-Cited by-同舟云学术

UCH-L1 is induced in germinal center B cells and identifies patients with aggressive germinal center diffuse large B-cell lymphoma

Published:2016-03-24 Issue:12 Volume:127 Page:1564-1574
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Bedekovics Tibor¹,Hussain Sajjad¹,Feldman Andrew L.²,Galardy Paul J.¹³⁴

Affiliation:

1. Department of Pediatric and Adolescent Medicine,

2. Department of Pathology and Laboratory Medicine,

3. Division of Pediatric Hematology-Oncology, and

4. Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, MN

Abstract

Key Points The neuronal marker UCH-L1 is induced in, and specifically augments the oncogene-induced transformation of, GCB cells. High levels of UCHL1 identify patients with GC DLBCL with an increased risk for poor outcomes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/12/1564/1392545/1564.pdf

Reference41 articles.

1. Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling.;Alizadeh;Nature,2000

2. Results of a randomized international study of high-risk central nervous system B non-Hodgkin lymphoma and B acute lymphoblastic leukemia in children and adolescents.;Cairo;Blood,2007

3. Relapsed/refractory diffuse large B-cell lymphoma.;Friedberg,2011

4. Activity-based ubiquitin-specific protease (USP) profiling of virus-infected and malignant human cells.;Ovaa;Proc Natl Acad Sci USA,2004

5. The de-ubiquitinase UCH-L1 is an oncogene that drives the development of lymphoma in vivo by deregulating PHLPP1 and Akt signaling.;Hussain;Leukemia,2010

Cited by 35 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The influence of CLEC5A on early macrophage-mediated inflammation in COPD progression;Cellular and Molecular Life Sciences;2024-08-04

2. Covalent Fragment Screening and Optimization Identifies the Chloroacetohydrazide Scaffold as Inhibitors for Ubiquitin C-terminal Hydrolase L1;Journal of Medicinal Chemistry;2024-03-15

3. Ubiquitin C‑terminal hydrolase‑L1: A new cancer marker and therapeutic target with dual effects (Review);Oncology Letters;2023-02-08

4. Establishment of an ovarian cancer omentum metastasis-related prognostic model by integrated analysis of scRNA-seq and bulk RNA-seq;Journal of Ovarian Research;2022-11-23

5. The Epstein–Barr virus noncoding RNA EBER2 transactivates the UCHL1 deubiquitinase to accelerate cell growth;Proceedings of the National Academy of Sciences;2021-10-22