Discordance in lymphoid tissue recovery following stem cell transplantation in rhesus macaques: an in vivo imaging study

Author:

Donahue Robert E.1,Srinivasula Sharat2,Uchida Naoya3,Kim Insook4,St. Claire Alexis5,Duralde Gorka5,DeGrange Paula6,St. Claire Marisa6,Reba Richard C.7,Bonifacino Aylin C.1,Krouse Allen E.1,Metzger Mark E.1,Paik Chang H.8,Lane H. Clifford9,Tisdale John F.3,Di Mascio Michele5

Affiliation:

1. Hematology Branch, National Heart, Lung, and Blood Institute (NHLBI), National Institutes of Health (NIH), Bethesda, MD;

2. Biostatistics Research Branch, Leidos Biomedical Research, Inc, Frederick National Laboratory for Cancer Research (FNLCR), Frederick, MD;

3. Molecular and Clinical Hematology Branch, NHLBI, NIH, Bethesda, MD;

4. Applied/Developmental Research Directorate, Leidos Biomedical Research, Inc, FNLCR, Frederick, MD;

5. Division of Clinical Research, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD;

6. Integrated Research Facility, NIAID, NIH, Frederick, MD; and

7. Center for Infectious Disease Imaging, Radiology and Imaging Sciences, Clinical Center,

8. Radiopharmaceutical Laboratory, Nuclear Medicine, Radiology and Imaging Sciences, Clinical Center, and

9. Laboratory of Immunoregulation, NIAID, NIH, Bethesda, MD

Abstract

Key Points Single-photon emission computed tomography imaging can be used to image immune recovery in lymphoid tissues following transplant. There is discordance between lymphoid tissues and the peripheral blood in numbers of CD4+ cells following various doses of irradiation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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