The ubiquitin ligase HERC4 mediates c-Maf ubiquitination and delays the growth of multiple myeloma xenografts in nude mice

Author:

Zhang Zubin1,Tong Jiefei2,Tang Xiaowen3,Juan Jiaxiang1,Cao Biyin1,Hurren Rose4,Chen Guodong1,Taylor Paul2,Xu Xin1,Shi Chang-xin5,Du Juan6,Hou Jian6,Wang Guanghui1,Wu Depei3,Stewart A. Keith5,Schimmer Aaron D.4,Moran Michael F.2,Mao Xinliang17

Affiliation:

1. Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China;

2. Program in Molecular Structure and Function, The Hospital for Sick Children, Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada;

3. Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, China;

4. Department of Hematology, Princess Margaret Cancer Center, University Health Network, University of Toronto, Toronto, ON, Canada;

5. Mayo Clinic, Scottsdale, AZ;

6. Department of Hematology, Changzheng Hospital, The Second Military Medical University, Shanghai, China; and

7. Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou, China

Abstract

Key Points HERC4 is the first identified ubiquitin ligase that mediates c-Maf ubiquitination and degradation. HERC4 suppresses MM cell proliferation and delays MM tumor growth.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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