Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma-Reference-Cited by-同舟云学术

Targeting HGF/c-MET induces cell cycle arrest, DNA damage, and apoptosis for primary effusion lymphoma

Published:2015-12-24 Issue:26 Volume:126 Page:2821-2831
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Dai Lu¹²³,Trillo-Tinoco Jimena⁴,Cao Yueyu²,Bonstaff Karlie³,Doyle Lisa³,Del Valle Luis⁴,Whitby Denise⁵,Parsons Chris³,Reiss Krzysztof³,Zabaleta Jovanny⁶,Qin Zhiqiang¹²

Affiliation:

1. Department of Microbiology, Immunology, & Parasitology, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans, LA;

2. Research Center for Translational Medicine and Key Laboratory of Arrhythmias, East Hospital, Tongji University School of Medicine, Shanghai, China;

3. Department of Medicine and

4. Department of Pathology, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans, LA;

5. Viral Oncology Section, AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD; and

6. Department of Pediatrics, Louisiana State University Health Sciences Center, Louisiana Cancer Research Center, New Orleans, LA

Abstract

Key Points The HGF/c-MET pathway has a complex network to control KSHV+ PEL cell survival. The c-MET inhibitor induces PEL apoptosis and suppresses tumor progression in vivo.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/126/26/2821/1390751/2821.pdf

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