Natural history and outcome of light chain deposition disease

Author:

Sayed Rabya H.12,Wechalekar Ashutosh D.1,Gilbertson Janet A.1,Bass Paul2,Mahmood Shameem1,Sachchithanantham Sajitha1,Fontana Marianna1,Patel Ketna1,Whelan Carol J.1,Lachmann Helen J.1,Hawkins Philip N.1,Gillmore Julian D.1

Affiliation:

1. National Amyloidosis Centre and

2. Centre for Nephrology, Division of Medicine, University College London, London, United Kingdom

Abstract

Key PointsDeep clonal responses to chemotherapy are associated with improved renal and overall outcomes in patients with light chain deposition disease. Deep clonal responses should be targeted, even in patients with advanced chronic kidney disease from light chain deposition disease.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference26 articles.

1. Manifestations of systemic light chain deposition.;Randall;Am J Med,1976

2. Renal monoclonal immunoglobulin deposition disease: a report of 64 patients from a single institution.;Nasr;Clin J Am Soc Nephrol,2012

3. Clinicopathological features and prognosis in immunoglobulin light and heavy chain deposition disease.;Masai;Clin Nephrol,2009

4. Kidney and liver involvement in monoclonal light chain disorders.;Pozzi;Semin Nephrol,2002

5. Receptor-mediated endocytosis of immunoglobulin light chains by renal proximal tubule cells.;Batuman;Am J Physiol,1997

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