Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma-Reference-Cited by-同舟云学术

Active IKKβ promotes the stability of GLI1 oncogene in diffuse large B-cell lymphoma

Published:2016-02-04 Issue:5 Volume:127 Page:605-615
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Agarwal Nitin K.¹,Kim Chae H.¹,Kunkalla Kranthi¹,Konno Hiroyasu²,Tjendra Youley¹,Kwon Deukwoo³,Blonska Marzenna⁴,Kozloski Goldi A.⁴,Moy Vincent T.⁵,Verdun Ramiro E.⁶,Barber Glen N.²,Lossos Izidore S.⁴⁷,Vega Francisco¹⁴

Affiliation:

1. Division of Hematopathology, Department of Pathology,

2. Department of Cell Biology,

3. Biostatistics and Bioinformatics Core,

4. Division of Hematology-Oncology, Department of Medicine,

5. Department of Physiology and Biophysics, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL;

6. Division of Gerontology and Geriatric Medicine, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL; and

7. Division of Hematology-Oncology, Department of Molecular and Cellular Pharmacology, Sylvester Comprehensive Cancer Center, University of Miami, Miami, FL

Abstract

Key Points IKKβ, independently of NF-κB, regulates the stability and transcriptional activity of GLI1 oncogene. Combined inhibition of IKKβ and GLI1 activities synergistically decreases DLBCL cell viability in vivo and in vitro.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/127/5/605/1394987/605.pdf

Reference44 articles.

1. The GLI gene is a member of the Kruppel family of zinc finger proteins.;Kinzler;Nature,1988

2. The GLI gene encodes a nuclear protein which binds specific sequences in the human genome.;Kinzler;Mol Cell Biol,1990

3. Transcriptional activation of hedgehog target genes in Drosophila is mediated directly by the cubitus interruptus protein, a member of the GLI family of zinc finger DNA-binding proteins.;Alexandre;Genes Dev,1996

4. Gli genes and limb development.;Theil;Cell Tissue Res,1999

5. Gli proteins and Hedgehog signaling: development and cancer.;Ruiz i Altaba;Trends Genet,1999

Cited by 17 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. P4HA2 hydroxylates SUFU to regulate the paracrine Hedgehog signaling and promote B-cell lymphoma progression;Leukemia;2024-06-22

2. Oncogenic KRASG12D Reprograms Lipid Metabolism by Upregulating SLC25A1 to Drive Pancreatic Tumorigenesis;Cancer Research;2023-09-11

3. Enhanced mitophagy driven by ADAR1-GLI1 editing supports the self-renewal of cancer stem cells in HCC;Hepatology;2023-01-24

4. Lymphoma‐associated mutations in autoreactive memory B cells of patients with Sjögren's syndrome;The Journal of Pathology;2023-01-12

5. A PDZ Protein GIPC3 Positively Modulates Hedgehog Signaling and Melanoma Growth;Journal of Investigative Dermatology;2022-01