HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency-Reference-Cited by-同舟云学术

HRI coordinates translation by eIF2αP and mTORC1 to mitigate ineffective erythropoiesis in mice during iron deficiency

Published:2018-01-25 Issue:4 Volume:131 Page:450-461
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhang Shuping¹^ORCID,Macias-Garcia Alejandra¹^ORCID,Velazquez Jason¹,Paltrinieri Elena¹,Kaufman Randal J.²,Chen Jane-Jane¹^ORCID

Affiliation:

1. Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA; and

2. Degenerative Diseases Program, Sanford Burnham Prebys Medical Discovery Institute, La Jolla, CA

Abstract

Key Points Erythroid eIF2αP and ATF4 are essential for iron-restricted erythropoiesis, and HRI-eIF2αP is responsible for microcytic hypochromic anemia. HRI activates integrated stress response and represses mTORC1 signaling in ID to mitigate ineffective erythropoiesis.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/4/450/1465805/blood799908.pdf

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