FOXP1 expression is a prognostic biomarker in follicular lymphoma treated with rituximab and chemotherapy

Author:

Mottok Anja123ORCID,Jurinovic Vindi45,Farinha Pedro12ORCID,Rosenwald Andreas3,Leich Ellen3ORCID,Ott German67ORCID,Horn Heike78,Klapper Wolfram9,Boesl Michael4,Hiddemann Wolfgang4,Steidl Christian12ORCID,Connors Joseph M.1ORCID,Sehn Laurie H.1,Gascoyne Randy D.12ORCID,Hoster Eva45,Weigert Oliver4ORCID,Kridel Robert10ORCID

Affiliation:

1. Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, BC, Canada;

2. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada;

3. Institute of Pathology, University of Würzburg and Comprehensive Cancer Centre Mainfranken, Würzburg, Germany;

4. Medical Department III, University Hospital, and

5. Institute for Medical Information Processing, Biometry and Epidemiology, Ludwig Maximilians University Munich, Munich, Germany;

6. Department of Clinical Pathology, Robert Bosch Hospital, Stuttgart, Germany;

7. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany;

8. University of Tübingen, Tübingen, Germany;

9. Department of Pathology, Hematopathology Section and Lymph Node Registry, University Kiel, Kiel, Germany; and

10. Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre–University Health Network, Toronto, ON, Canada

Abstract

Key Points High expression of FOXP1 predicts adverse FFS in patients with FL treated with immunochemotherapy. FOXP1 high and low expressors differ in specific gene mutations and gene expression changes.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference61 articles.

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