MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia-Reference-Cited by-同舟云学术

MPL expression on AML blasts predicts peripheral blood neutropenia and thrombocytopenia

Published:2016-11-03 Issue:18 Volume:128 Page:2253-2257
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rauch Philipp J.¹²,Ellegast Jana M.¹,Widmer Corinne C.¹,Fritsch Kristin¹,Goede Jeroen S.¹,Valk Peter J. M.³,Löwenberg Bob³,Takizawa Hitoshi¹⁴,Manz Markus G.¹

Affiliation:

1. Hematology, University Hospital and University of Zurich, Zurich, Switzerland;

2. Department of Medicine, Boston University School of Medicine, Boston, MA;

3. Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands; and

4. International Research Center for Medical Sciences, Kumamoto University, Kumamoto, Japan

Abstract

Key Points AML-associated peripheral blood cytopenia is independent of bone marrow blast content, but strongly predicted by MPL expression on blast cells. MPLhi blasts scavenge TPO from serum, causing insufficient cytokine levels.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/18/2253/1396450/2253.pdf

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4. Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin.;Kaushansky;Nature,1994

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