T cells expressing an anti–B-cell maturation antigen chimeric antigen receptor cause remissions of multiple myeloma

Author:

Ali Syed Abbas1,Shi Victoria2,Maric Irina3,Wang Michael4,Stroncek David F.5,Rose Jeremy J.2,Brudno Jennifer N.1,Stetler-Stevenson Maryalice6,Feldman Steven A.7,Hansen Brenna G.2,Fellowes Vicki S.2,Hakim Frances T.2,Gress Ronald E.2,Kochenderfer James N.2

Affiliation:

1. Center for Cancer Research, and

2. Experimental Transplantation and Immunology Branch, National Cancer Institute, National Institutes of Health (NIH), Bethesda, MD;

3. Department of Laboratory Medicine, Clinical Center, NIH, Bethesda, MD;

4. University of Texas MD Anderson Cancer Center, Houston, TX;

5. Department of Transfusion Medicine, Clinical Center, NIH, Bethesda, MD;

6. Laboratory of Pathology, and

7. Surgery Branch, National Cancer Institute, NIH, Bethesda, MD

Abstract

Key Points Anti-BCMA T cells have impressive activity against MM.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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