Corticosteroids compared with intravenous immunoglobulin for the treatment of immune thrombocytopenia in pregnancy

Author:

Sun Dongmei1,Shehata Nadine23,Ye Xiang Y.4,Gregorovich Sandra5,De France Bryon5,Arnold Donald M.67,Shah Prakesh S.8,Malinowski Ann Kinga9

Affiliation:

1. Department of Medicine, Schulich School of Medicine and Dentistry, Western University, London, ON, Canada;

2. Departments of Medicine, Laboratory Medicine, and Pathobiology, and Institute of Health Policy, Management, and Evaluation, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada;

3. Canadian Blood Services, Toronto, ON, Canada;

4. Maternal-Infant Care Research Centre, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada;

5. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, and

6. Department of Medicine, McMaster University, Hamilton, ON, Canada;

7. Canadian Blood Services, Hamilton, ON, Canada; and

8. Department of Paediatrics and Institute of Health Policy, Management and Evaluation, and

9. Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Mount Sinai Hospital, University of Toronto, Toronto, ON, Canada

Abstract

Key Points Maternal platelet count response was not different for IVIg and corticosteroids in this retrospective study of pregnant women with ITP. Neonatal outcomes were overall favorable and similar after treatment of maternal ITP with IVIg or corticosteroids.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference38 articles.

1. ACOG practice bulletin: Thrombocytopenia in pregnancy. Number 6, September 1999. Clinical management guidelines for obstetrician-gynecologists.;American College of Obstetricians and Gynecologists;Int J Gynaecol Obstet,1999

2. A retrospective 11-year analysis of obstetric patients with idiopathic thrombocytopenic purpura.;Webert;Blood,2003

3. Idiopathic thrombocytopenic purpura in pregnancy: Analysis of 43 consecutive cases followed at a single Italian institution.;Veneri;Ann Hematol,2006

4. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia.;Neunert;Blood,2011

5. How I treat thrombocytopenia in pregnancy.;Gernsheimer;Blood,2012

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