Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice-Reference-Cited by-同舟云学术

Disulfide HMGB1 derived from platelets coordinates venous thrombosis in mice

Published:2016-11-17 Issue:20 Volume:128 Page:2435-2449
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Stark Konstantin¹²,Philippi Vanessa¹,Stockhausen Sven¹,Busse Johanna¹,Antonelli Antonella³,Miller Meike¹,Schubert Irene¹,Hoseinpour Parandis¹,Chandraratne Sue¹,von Brühl Marie-Luise¹,Gaertner Florian¹²,Lorenz Michael¹,Agresti Alessandra³,Coletti Raffaele¹,Antoine Daniel J.⁴,Heermann Ralf⁵,Jung Kirsten⁵,Reese Sven⁶,Laitinen Iina⁷,Schwaiger Markus⁷,Walch Axel⁸,Sperandio Markus²⁹,Nawroth Peter P.¹⁰,Reinhardt Christoph¹¹¹²,Jäckel Sven¹¹¹²,Bianchi Marco E.³,Massberg Steffen¹²

Affiliation:

1. Medizinische Klinik I, Ludwig-Maximilians-Universität, Munich, Germany;

2. German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany;

3. Chromatin Dynamics Unit, San Raffaele University and Scientific Institute, Milan, Italy;

4. Medical Research Council Center for Drug Safety Science, Department of Molecular and Clinical Pharmacology, University of Liverpool, Liverpool, United Kingdom;

5. Munich Center for Integrated Protein Science, Department of Biology I, and

6. Lehrstuhl für Anatomie, Histologie und Embryologie, Faculty of Veterinary Medicine, Ludwig-Maximilians Universität, Munich, Germany;

7. Nuklearmedizinische Klinik und Poliklinik, Klinikum rechts der Isar, Technische Universität München, Munich, Germany;

8. Helmholtz Zentrum München, Deutsches Forschungszentrum für Umwelt und Gesundheit, Institut für Pathologie, Neuherberg, Germany;

9. Walter Brendel Centre of Experimental Medicine, Ludwig-Maximilians-Universität, Munich, Germany;

10. Department of Internal Medicine I and Clinical Chemistry, University of Heidelberg, Heidelberg, Germany;

11. Center for Thrombosis and Hemostasis University Medical Center Mainz, Mainz, Germany; and

12. German Center for Cardiovascular Research, Partner Site RheinMain, Mainz, Germany

Abstract

Key Points Sterile inflammation inducing venous thrombosis is coordinated by the damage-associated molecular pattern HMGB1 delivered by platelets. The effect of HMGB1 depends on the redox form, and disulfide HMGB1 induces NET formation, platelet aggregation, and monocyte activation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/128/20/2435/1397303/blood710632.pdf

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