Expressions of the CagA protein and CagA-signaling molecules predict Helicobacter pylori dependence of early-stage gastric DLBCL-Reference-Cited by-同舟云学术

Expressions of the CagA protein and CagA-signaling molecules predict Helicobacter pylori dependence of early-stage gastric DLBCL

Published:2017-01-12 Issue:2 Volume:129 Page:188-198
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Kuo Sung-Hsin¹²³⁴^ORCID,Chen Li-Tzong⁵⁶⁷,Lin Chung-Wu⁸,Yeh Kun-Huei¹³⁴,Shun Chia-Tung⁸,Tzeng Yi-Shin¹⁴,Liou Jyh-Ming²,Wu Ming-Shiang²,Hsu Ping-Ning²,Cheng Ann-Lii¹²³⁴⁵

Affiliation:

1. Department of Oncology and

2. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan;

3. National Taiwan University Cancer Center and

4. Graduate Institute of Oncology, College of Medicine, National Taiwan University, Taipei, Taiwan;

5. National Institute of Cancer Research, National Health Research Institutes, Tainan, Taiwan;

6. Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan;

7. Department of Internal Medicine, National Cheng-Kung University Hospital, Tainan, Taiwan; and

8. Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan

Abstract

Key Points Expression of CagA and CagA-signaling molecules p-SHP2 and p-ERK is associated with HP dependence of gastric DLBCL. CagA is associated with the direct lymphomagenic effect of HP on B cells of HP-dependent gastric DLBCL.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/129/2/188/1400495/blood713719.pdf

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