Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells-Reference-Cited by-同舟云学术

Antigen-armed antibodies targeting B lymphoma cells effectively activate antigen-specific CD4+ T cells

Published:2015-03-05 Issue:10 Volume:125 Page:1601-1610
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Yu Xiaojun¹²,Ilecka Marta¹²,Bartlett Emmalene J.¹²,Schneidt Viktor¹²,Bhat Rauf³,Mautner Josef⁴⁵,Feederle Regina¹²,Delecluse Henri-Jacques¹²⁶

Affiliation:

1. German Cancer Research Centre (DKFZ) Unit F100, Heidelberg, Germany;

2. Institut National de la Santé et de la Recherche Médicale Unit U1074, Heidelberg, Germany;

3. German Cancer Research Centre Unit F010, Heidelberg, Germany;

4. Clinical Cooperation Group Pediatric Tumor Immunology, Helmholtz-Zentrum München, München, Germany;

5. Children's Hospital, Technische Universität München, München, Germany; and

6. German Centre for Infection Research (DZIF), Heidelberg, Germany

Abstract

Key PointsEpitopes in antigen-armed antibodies that target B-cell receptors are efficiently presented by B lymphoma cells to cytotoxic CD4+ T cells. Memory T cells activated by AgAbs ex vivo are able to kill targeted B lymphoma cells.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/10/1601/1383376/1601.pdf

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