Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation-Reference-Cited by-同舟云学术

Lung parenchyma-derived IL-6 promotes IL-17A–dependent acute lung injury after allogeneic stem cell transplantation

Published:2015-04-09 Issue:15 Volume:125 Page:2435-2444
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Varelias Antiopi¹,Gartlan Kate H.¹,Kreijveld Ellen¹,Olver Stuart D.¹,Lor Mary¹,Kuns Rachel D.¹,Lineburg Katie E.¹,Teal Bianca E.¹,Raffelt Neil C.¹,Cheong Melody¹,Alexander Kylie A.¹,Koyama Motoko¹,Markey Kate A.¹,Sturgeon Elise¹²,Leach Justine¹²,Reddy Pavan³,Kennedy Glen A.¹²,Yanik Gregory A.³,Blazar Bruce R.⁴,Tey Siok-Keen¹²,Clouston Andrew D.⁵,MacDonald Kelli P. A.¹,Cooke Kenneth R.⁶,Hill Geoffrey R.¹²

Affiliation:

1. QIMR Berghofer Medical Research Institute, Brisbane, QLD, Australia;

2. Department of Bone Marrow Transplantation, The Royal Brisbane and Women’s Hospital, Brisbane, QLD, Australia;

3. Division of Hematology and Oncology, Blood and Marrow Transplantation Program, University of Michigan, Ann Arbor, MI;

4. Masonic Cancer Center and Department of Pediatrics, Division of Blood and Marrow Transplantation, University of Minnesota, Minneapolis, MN;

5. Envoi Specialist Pathologists, Brisbane, QLD, Australia; and

6. Department of Oncology, Blood and Marrow Stem Cell Transplantation Program, Sidney Kimmel Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD

Abstract

Key Points IL-6 is dysregulated after experimental allogeneic SCT and promotes alloantigen-dependent Th17 expansion within the lung. IL-6 is dysregulated in patients with IPS after clinical allogeneic SCT.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/125/15/2435/1383960/2435.pdf

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4. The lung as a target organ of graft-versus-host disease.;Yanik;Semin Hematol,2006

5. IFNgamma differentially controls the development of idiopathic pneumonia syndrome and GVHD of the gastrointestinal tract.;Burman;Blood,2007

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