Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion-Reference-Cited by-同舟云学术

Outcome of children with acute leukemia given HLA-haploidentical HSCT after αβ T-cell and B-cell depletion

Published:2017-08-03 Issue:5 Volume:130 Page:677-685
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Locatelli Franco¹²,Merli Pietro¹,Pagliara Daria¹,Li Pira Giuseppina¹,Falco Michela³,Pende Daniela⁴,Rondelli Roberto⁵,Lucarelli Barbarella¹,Brescia Letizia Pomponia¹,Masetti Riccardo⁵,Milano Giuseppe Maria¹,Bertaina Valentina¹,Algeri Mattia¹,Pinto Rita Maria¹,Strocchio Luisa¹,Meazza Raffaella⁴,Grapulin Lavinia⁶,Handgretinger Rupert⁷,Moretta Alessandro⁸,Bertaina Alice¹,Moretta Lorenzo⁹

Affiliation:

1. Department of Pediatric Hematology and Oncology, Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Bambino Gesù, Rome, Italy;

2. Department of Pediatric Science, Università di Pavia, Pavia, Italy;

3. Dipartimento di Ricerca e Diagnostica, UOC Immunologia Clinica e Sperimentale, Istituto di Ricovero e Cura a Carattere Scientifico Giannina Gaslini, Genoa, Italy;

4. UOC Immunologia, Ospedale Policlinico San Martino, Genoa, Italy;

5. Department of Pediatrics, Sant’Orsola Hospital, University of Bologna, Bologna, Italy;

6. Department of Radiotherapy, Policlinico Umberto I, Rome, Italy;

7. Department of Pediatric Hematology and Oncology, Children's University Hospital, University of Tuebingen, Tuebingen, Germany;

8. Dipartimento di Medicina Sperimentale and Centro di Eccellenza per la Ricerca Biomedica, Università di Genova, Genoa, Italy; and

9. Immunology Research Area, IRCCS Ospedale Bambino Gesù, Rome, Italy

Abstract

Key Points Children with AL given haplo-HSCT after αβ T- and B-cell depletion are exposed to a low risk of acute and chronic GVHD and NRM. The leukemia-free, GVHD-free survival of patients given this type of allograft is comparable to that of HLA-matched donor HSCT recipients.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/5/677/1404269/blood779769.pdf

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