DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions-Reference-Cited by-同舟云学术

DNMT3A and TET2 dominate clonal hematopoiesis and demonstrate benign phenotypes and different genetic predispositions

Published:2017-08-10 Issue:6 Volume:130 Page:753-762
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Buscarlet Manuel¹^ORCID,Provost Sylvie²,Zada Yassamin Feroz²,Barhdadi Amina²,Bourgoin Vincent¹,Lépine Guylaine¹,Mollica Luigina¹³⁴,Szuber Natasha³⁴,Dubé Marie-Pierre²⁴^ORCID,Busque Lambert¹³⁴^ORCID

Affiliation:

1. Research Centre Centre Intégré Universitaire de Santé et de Services Sociaux (CIUSSS) de l’Est-de-l’île de Montréal, Installation Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada;

2. Beaulieu-Saucier Pharmacogenomics Centre, Montreal Heart Institute Research Centre, Montreal, QC, Canada;

3. Hematology Division, CIUSSS de l’Est-de-l’île de Montréal, Installation Hôpital Maisonneuve-Rosemont, Montreal, QC, Canada; and

4. Université de Montréal, Montreal, QC, Canada

Abstract

Key Points Somatic mutations driving clonal hematopoiesis occur mainly in DNMT3A and TET2 and have no significant impact on hematological phenotypes. There is a familial predisposition to acquire TET2 mutation.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/130/6/753/1404731/blood777029.pdf

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