mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8-Reference-Cited by-同舟云学术

mTOR masters monocyte development in bone marrow by decreasing the inhibition of STAT5 on IRF8

Published:2018-04-05 Issue:14 Volume:131 Page:1587-1599
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Zhao Yang¹²,Shen Xiaofei¹,Na Ning³,Chu Zhulang¹,Su Huiting¹,Chao Shanshan¹,Shi Lu¹,Xu Yanan¹,Zhang Lianfeng⁴⁵,Shi Bingyi⁶,Zhao Yong¹

Affiliation:

1. State Key Laboratory of Membrane Biology, Institute of Zoology and

2. University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing, China;

3. Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China;

4. Key Laboratory of Human Diseases Comparative Medicine, Ministry of Health, Beijing, China;

5. Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences, Beijing, China; and

6. Organ Transplantation Center of People’s Liberation Army, 309 Hospital of Chinese People’s Liberation Army, Beijing, China

Abstract

Key Points mTOR intrinsically controls monocyte/macrophage development in the early stage. mTOR masters monocyte development via the STAT5-IRF8-CD115 pathway.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/14/1587/1406150/blood777128.pdf

Reference68 articles.

1. CX3CR1+ CD115+ CD135+ common macrophage/DC precursors and the role of CX3CR1 in their response to inflammation;Auffray;J Exp Med,2009

2. The dendritic cell lineage: ontogeny and function of dendritic cells and their subsets in the steady state and the inflamed setting;Merad;Annu Rev Immunol,2013

3. Development of monocytes, macrophages, and dendritic cells;Geissmann;Science,2010

4. Differentiation, maturation, and proliferation of macrophages in the mouse yolk sac: a light-microscopic, enzyme-cytochemical, immunohistochemical, and ultrastructural study;Takahashi;J Leukoc Biol,1989

5. Origin, development, and homeostasis of tissue-resident macrophages;Haldar;Immunol Rev,2014

Cited by 39 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Microbiota-derived butyrate inhibits cDC development via HDAC inhibition, diminishing their ability to prime T cells;Mucosal Immunology;2024-08

2. Fraxetin pretreatment alleviates cisplatin‐induced kidney injury by antagonizing autophagy and apoptosis via mTORC1 activation;Phytotherapy Research;2024-04

3. STAT5 is essential for inducing the suppressive subset and attenuate cytotoxicity of Vδ2+ T cells in acute myeloid leukemia;Cancer Letters;2024-04

4. C/EBPα mediates the maturation and antitumor functions of macrophages in human hepatocellular carcinoma;Cancer Letters;2024-03

5. Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes;Cell Reports;2024-01