S100-A9 protein in exosomes from chronic lymphocytic leukemia cells promotes NF-κB activity during disease progression

Abstract

Key Points Plasma-derived exosomes from patients with CLL exhibit different protein cargo compositions depending on disease status and progression. S100-A9 protein is overexpressed and S100-A9 cargo in exosomes activates NF-κB pathway in patients with CLL during disease progression.