Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling-Reference-Cited by-同舟云学术

Identification of the integrin-binding site on coagulation factor VIIa required for proangiogenic PAR2 signaling

Published:2018-02-08 Issue:6 Volume:131 Page:674-685
ISSN:0006-4971
Container-title:Blood
language:en
Short-container-title:

Author:

Rothmeier Andrea S.¹,Liu Enbo²,Chakrabarty Sagarika¹,Disse Jennifer¹,Mueller Barbara M.²,Østergaard Henrik³,Ruf Wolfram¹⁴

Affiliation:

1. Department of Immunology and Microbiology, The Scripps Research Institute, La Jolla, CA;

2. San Diego Biomedical Research Institute, San Diego, CA;

3. Novo Nordisk A/S, Maløv, Denmark; and

4. Center for Thrombosis and Hemostasis, Johannes Gutenberg University Medical Center, Mainz, Germany

Abstract

Key Points The FVIIa integrin-binding motif is required for TF-FVIIa complex formation with integrin β1 and proangiogenic signaling. The arf6 integrin recycling pathway controls TF-FVIIa signaling and cell surface availability for procoagulant activity.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Link

http://ashpublications.org/blood/article-pdf/131/6/674/1466649/blood768218.pdf

Reference68 articles.

1. Tissue factor-factor VIIa-specific up-regulation of IL-8 expression in MDA-MB-231 cells is mediated by PAR-2 and results in increased cell migration;Hjortoe;Blood,2004

2. Factor VIIa/tissue factor-induced signaling via activation of Src-like kinases, phosphatidylinositol 3-kinase, and Rac;Versteeg;J Biol Chem,2000

3. Binding of factor VIIa to tissue factor on keratinocytes induces gene expression;Camerer;J Biol Chem,2000

4. Factor VIIa/tissue factor-dependent gene regulation and pro-coagulant activity: effect of factor VIIa concentration;Petersen;Thromb Haemost,2007

5. Disulfide isomerization switches tissue factor from coagulation to cell signaling;Ahamed;Proc Natl Acad Sci USA,2006

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