FDG-PET–driven consolidation strategy in diffuse large B-cell lymphoma: final results of a randomized phase 2 study

Author:

Casasnovas R.-O.1,Ysebaert L.2,Thieblemont C.3,Bachy E.4,Feugier P.5,Delmer A.6,Tricot S.7,Gabarre J.8,Andre M.9,Fruchart C.10,Mounier N.11,Delarue R.12,Meignan M.13,Berriolo-Riedinger A.14,Bardet S.15,Emile J.-F.1617,Jais J.-P.18,Haioun C.19,Tilly H.20,Morschhauser F.21

Affiliation:

1. Department of Hematology, Hôpital Le Bocage and INSERM Unité Mixte de Recherche1231, Dijon, France;

2. Department of Hematology, Institut Universitaire du Cancer de Toulouse-Oncopole, Toulouse, France;

3. Department of Hematology, Assistance Publique–Hôpitaux de Paris (APHP), Hôpital Saint Louis, Université Paris Diderot-Sorbonne Paris-Cité, Paris, France;

4. Department of Hematology, Hôpital Lyon Sud, Pierre Bénite, France;

5. Department of Hematology, University Hospital of Nancy, Vandoeuvre les Nancy, France;

6. Department of Hematology, University Hospital of Reims, Reims, France;

7. Department of Hematology, Hospital of Valenciennes, Valenciennes, France;

8. Department of Hematology, Hôpital Pitié Salpetrière, Paris, France;

9. Department of Hematology, Centre Hospitalier Universitaire, Université Catholique de Louvain Namur, Université Catholique de Louvain, Yvoir, Belgium;

10. Department of Hematology, Institut d’hématologie de Basse Normandie, Caen, France;

11. Department of Hematology, University Hospital of Nice, Nice, France;

12. Department of Hematology, Hôpital Necker, Paris, France;

13. Department of Nuclear Medicine, Hôpital H. Mondor, Creteil, France;

14. Department of Nuclear Medicine, Centre G. F. Leclerc, Dijon, France;

15. Department of Nuclear Medicine, Centre F. Baclesse, Caen, France;

16. Department of Pathology, APHP, Hôpital Ambroise-Paré, Boulogne, France;

17. Department of Pathology, EA430 Université de Versailles, Versailles, France;

18. Department of Biostatistics, Hôpital Necker, Paris, France;

19. Department of Hematology, Hôpital H. Mondor, Creteil, France;

20. Department of Hematology, Centre H. Becquerel, Rouen, France; and

21. Department of Hematology, Hôpital Claude Huriez, Université Lille, EA 7365, Groupe de Recherche sur les formes Injectables et les Technologies Associées, Lille, France

Abstract

Key Points Superiority of R-ACVBP over R-CHOP14 was not established, as IHP criteria driving consolidation did not properly reflect disease control. The 26% PET2−/PET4− patients using IHP criteria increased to 79% using ΔSUVmax, which may help better select those needing an alternative to SIC.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

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