Ferritin is secreted via 2 distinct nonclassical vesicular pathways

Author:

Truman-Rosentsvit Marianna1ORCID,Berenbaum Dina1,Spektor Lior1,Cohen Lyora A.1,Belizowsky-Moshe Shirly1,Lifshitz Lena1,Ma Jing2,Li Wei2,Kesselman Ellina3,Abutbul-Ionita Inbal3,Danino Dganit3,Gutierrez Lucia4,Li Huihui5,Li Kuanyu5,Lou Huifang6,Regoni Maria7,Poli Maura7,Glaser Fabian8,Rouault Tracey A.9,Meyron-Holtz Esther G.1ORCID

Affiliation:

1. Laboratory for Molecular Nutrition, Faculty of Biotechnology and Food Engineering, Technion, Technion City, Haifa, Israel;

2. Center for Medical Genetics, Beijing Children’s Hospital, Capital Medical University, Beijing Pediatric Research Institute, MOE Key Laboratory of Major Diseases in Children, Beijing, China;

3. CryoEM Laboratory of Soft Matter, Faculty of Biotechnology and Food Engineering, Technion, Technion City, Haifa, Israel;

4. Departamento de Química Analítica, Instituto de Nanociencia de Aragón, Universidad de Zaragoza, Zaragoza, Spain;

5. Medical School of Nanjing University, Nanjing, China;

6. Department of Neurobiology, Zhejiang University School of Medicine, Hangzhou, China;

7. Department of Molecular and Translational Medicine, Università degli Studi di Brescia, Brescia, Italy;

8. The Lorry I. Lokey Interdisciplinary Center for Life Sciences and Engineering, Technion, Technion City, Haifa, Israel; and

9. Molecular Medicine Program, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD

Abstract

Key Points Iron-loaded ferritin is secreted via both the nonclassical secretory autophagy and multivesicular body–exosome pathways. A motif on both ferritin subunits is involved in the regulation of ferritin secretion.

Publisher

American Society of Hematology

Subject

Cell Biology,Hematology,Immunology,Biochemistry

Reference79 articles.

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4. The regulation of iron transport;Frazer;Biofactors,2014

5. Iron metabolism in the reticuloendothelial system;Knutson;Crit Rev Biochem Mol Biol,2003

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